Gabaergic system role in aqueous extract of Valeriana officinalis L. root on PTZ-induced clonic seizure threshold in mice
نویسندگان
چکیده
منابع مشابه
the effect of aqueous extract of garlic on formalin-induced pain in male rats
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15 صفحه اولInvolvement of GABAergic System in Increased Pentylenetetrazole-Induced Seizure Threshold in Cholestatic Mice
Gamma-aminobutyric acid (GABA) is an important inhibitory transmitter in central nervous system and is involved in pathophysiology of epilepsy. Pentylenete-trazole (PTZ), a convulsant agent, partly acts via anion channel of GABAA receptor. Ivermectin, an antiparasitic agent and a GABAA agonist, has anticonvulsant effect in animal seizure models. Cholestasis increases ...
متن کاملEffects of Valeriana Officinalis Extract on the Seizure Induced by Picrotoxin in Mice
Neurological effects of Valeriana officinalis have been recognized for many years. In this study, the anticonvulsant activity of methanolic extract of the plant were investigated in mice. Picrotoxin with doses of 6 and 12.5 mg/kg were used for induction of seizures. The effects of different doses of methanolic extract of the plant on the variation of beginning time of seizures, the incidence of...
متن کاملinvolvement of gabaergic system in increased pentylenetetrazole-induced seizure threshold in cholestatic mice
gamma-aminobutyric acid (gaba) is an important inhibitory transmitter in central nervous system and is involved in pathophysiology of epilepsy. pentylenete-trazole (ptz), a convulsant agent, partly acts via anion channel of gabaa receptor. ivermectin, an antiparasitic agent and a gabaa agonist, has anticonvulsant effect in animal seizure models. cholestasis increases the threshold of ptz-induce...
متن کاملEvaluation of Hepatotoxicity of Aqueous Extract of Valerian (Valeriana Officinalis) in Laboratory Mice
Introduction: Concerns have been raised about the toxic effects of medicinal plants due to their increased consumption. Therefore, the aim of the present study was to investigate the hepatotoxic effects of aqueous extract of valerian in laboratory mice. Methods: After preparation of plant materials and aqueous extract of valerian, concentrations of 10 and 20 mg/kg body weight were administered...
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ژورنال
عنوان ژورنال: African Journal of Pharmacy and Pharmacology
سال: 2011
ISSN: 1996-0816
DOI: 10.5897/ajpp11.241